CYTOTOXICITY EFFECTS AND CHEMOTHERAPY IMPROVEMENT OF COCOA AGAINST CHRONIC MYELOCYTIC LEUKEMIA CELL LINE (K562) (Atena Editora)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributor.authorlopes, aline costa-
Data de aceite: dc.date.accessioned2024-08-29T06:00:10Z-
Data de disponibilização: dc.date.available2024-08-29T06:00:10Z-
Data de envio: dc.date.issued2024-08-28-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/869222-
Resumo: dc.description.abstractThis study aimed to analyze the anticarcinogenic activity and in vitro response to chemotherapy of cocoa in chronic myeloid leukemia (CML) cell line (K562). Cells were exposed to different concentrations of cocoa (30; 100; 500; 750; 1000; 1500 and 2000 μg/mL) isolated and associated with ATRA and arsenic trioxide during 24 and 72 hours. Our results indicate that cocoa showed selective cytotoxic action on K562 cells at all concentrations tested in 72 hours. Moreover, cocoa raised oxidative stress by increasing levels of total levels of ROS, nitric oxide, and superoxide. Also, cocoa improved the action of chemotherapy, by reducing cell viability and proliferation. Thus, the results highlight cocoa as a potent anticancer agent, with an excellent selective profile to be used adjuvant therapies for CML.pt_BR
Idioma: dc.language.isoenpt_BR
Palavras-chave: dc.subjectCYTOTOXICITYpt_BR
Título: dc.titleCYTOTOXICITY EFFECTS AND CHEMOTHERAPY IMPROVEMENT OF COCOA AGAINST CHRONIC MYELOCYTIC LEUKEMIA CELL LINE (K562) (Atena Editora)pt_BR
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