EFFECTIVENESS OF DIETARY SUPPLEMENTATION WITH UBIQUINONE, IN USE OF STATINS, IN THE PREVENTION OF MYOPATHIES (Atena Editora)

Abstract

HMG-CoA reductase inhibitors or statins act on the mevalonate pathway, preventing the formation of GPP (geranyl pyrophosphate) and consequently the formation of isoprenoids such as dolichols and ubiquinone, which are used in mitochondrial metabolism to produce ATP (adenosine triphosphate). and its lack leads to the development of statin-related muscle symptoms (SMRE). The entire theoretical reference of the research was taken from the PubMed, Google Scholar and Scielo databases, over the last 5 years, in Portuguese, English and Spanish, the Boolean operator used was “AND”, 49 articles were found, from which we selected -se 10. Studies have demonstrated the effectiveness of ubiquinone in the treatment of SMRE, as by acting directly on the pathophysiology that involves the decrease in ATP and the impairment of muscle function, it promotes a quantifiable improvement in fatigue, pain and other muscle symptoms. While some studies reported doubt regarding the efficiency of CoQ10, others expressly denied the beneficial effects of ubiquinone supplementation. During the research, factors were found that limited further investigation into the subject, which were the scarcity of studies that followed supplementation with ubiquinone over a prolonged period, the failure to establish an effective dosage for the use of CoQ10 to prevent ERMS, in addition to the little attention to the comorbidities and lifestyle habits that were related to the pathology of the patients studied. The supplementary use of CoQ10 showed positive results when used individually. In this way, it proved to be a highly viable option to prevent ERMS, even though there is not yet the diversity of studies necessary to establish medical management.