ANALYSIS OF THE ANTIDEPRESSANT POTENTIAL OF PHYSICAL EXERCISE PRACTICE, MEDIATED BY NEUROPLASTICITY, IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER: A SYSTEMATIC REVIEW ARTICLE

Abstract

Introduction: Major Depressive Disorder is a common mental disorder, characterized by high incidence, disability and fatality, culminating in a significant burden on society. Changes in brain plasticity may be a reason for Depression, and recent studies show that physical exercise plays a positive role in depression. Goal: In order to better understand the antidepressant effect of exercise and changes in brain plasticity, the present study explores the relationship between depression, brain plasticity and the positive role of physical exercise in treatment. Methodology: Given the above, related literature was retrieved using specific descriptors from the Cochrane Central Register of Controlled Trials (CENTRAL) database, MEDLINE, Embase, China National Knowledge Infrastructure (CNKI) and PubMed. Result: Increased exercise was negatively correlated with the risk of depression, that is, clinical trials demonstrate that aerobic, resistance and mind-body exercises can improve depressive symptoms. Evidence indicates that exercise remodels brain structure, activates related brain areas, promotes behavioral adaptation, and maintains the integrity of the hippocampus and white matter. Although exercise has benefits in brain neuroprocessing, slowing cognitive degradation in depressed patients, the intensity and long-term effects still need to be clarified. Conclusion: Therefore, future research is crucial to establish accurate exercise prescriptions aimed at improving depressive symptoms.