EVALUATION OF PULMONARY CHANGES CAUSED BY INDUCED SEPSIS AND THE USE OF PROPRANOLOL IN ENDOTHELIAL DYSFUNCTION IN WISTAR RATS (Atena Editora)

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Autor(es): dc.contributor.authorVARGAS, THAMIRIS SILVA DOS SANTOS-
Autor(es): dc.contributor.authorANTUNES, FERNANDA-
Autor(es): dc.contributor.authorLEANDRO, HASSAN JERDY-
Autor(es): dc.contributor.authorMELLO, LUCIANA DE MACÊDO-
Autor(es): dc.contributor.authorMORALES, ISABELLA CRISTINA-
Autor(es): dc.contributor.authorMONTEIRO, THERESA DE MOURA-
Autor(es): dc.contributor.authorVIANA, LETICIA RAMOS-
Autor(es): dc.contributor.authorPÓVOA, DHARA MIRANDA MACHADO-
Autor(es): dc.contributor.authorTORRES, JÉSSICA DORNELES-
Autor(es): dc.contributor.authorBRAGA, GUSTAVO D’ANUNCIAÇÃO-
Data de aceite: dc.date.accessioned2023-08-07T14:10:23Z-
Data de disponibilização: dc.date.available2023-08-07T14:10:23Z-
Data de envio: dc.date.issued2023-07-21-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/735602-
Resumo: dc.description.abstractObjective: To evaluate the potential effect of propranolol as a possible lung protector on endothelial dysfunction in cases of induced sepsis in Wistar rats. Methods: The animals were divided into 3 groups: Group 1, intraperitoneal propranolol administration 30 minutes before sepsis induction; Group 2, administration of intraperitoneal propranolol 30 minutes after sepsis induction; Group 3, SHAM (control), septic animals without propranolol administration. For evaluation, hemorrhage, edema, atelectasis and pneumonia scores were used as tissue damage criteria. Results: Propranolol was found to protect against pneumonia and atelectasis, but increased bleeding while edema remained mild in all groups. Final considerations: The results showed that the treated groups showed clinical improvement in different aspects during the sepsis period, with a survival of treated animals when compared to untreated ones.pt_BR
Idioma: dc.language.isoenpt_BR
Palavras-chave: dc.subjectPneumoniapt_BR
Título: dc.titleEVALUATION OF PULMONARY CHANGES CAUSED BY INDUCED SEPSIS AND THE USE OF PROPRANOLOL IN ENDOTHELIAL DYSFUNCTION IN WISTAR RATS (Atena Editora)pt_BR
Tipo de arquivo: dc.typelivro digitalpt_BR
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