PRELIMINARY RESULTS IN THE EVALUATION OF THE CHEMOTHERAPY ACTIVITY OF BETA-SITOSTEROL IN A MODEL OF OSTEOSARCOMA IN RATS (Atena Editora)

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Autor(es): dc.contributor.authorPÉREZ, ROGELIO PANIAGUA-
Autor(es): dc.contributor.authorMADRIGAL BUJAIDAR, EDUARDO-
Autor(es): dc.contributor.authorÁLVAREZ GONZÁLEZ, ISELA-
Autor(es): dc.contributor.authorARAUJO MONSALVO, VICTOR M-
Autor(es): dc.contributor.authorDOMÍNGUEZ HERNÁNDEZ, VICTOR M-
Autor(es): dc.contributor.authorMARTÍNEZ CANSECO, CARLOS-
Autor(es): dc.contributor.authorGARCÍA CAMPILLO, HIRAM-
Autor(es): dc.contributor.authorCRUZ HERNÁNDEZ, LIDIA-
Autor(es): dc.contributor.authorQUINTANA ARMENTA, ALEJANDRA-
Autor(es): dc.contributor.authorRUÍZ ROSANO, LIDIA-
Autor(es): dc.contributor.authorMARTÍNEZ CORIA, ELISA-
Autor(es): dc.contributor.authorFRANCO Y BOURLAND, REBECCA E-
Data de aceite: dc.date.accessioned2023-07-17T11:48:30Z-
Data de disponibilização: dc.date.available2023-07-17T11:48:30Z-
Data de envio: dc.date.issued2023-06-30-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/734300-
Resumo: dc.description.abstractOsteosarcoma (OS) is a malignant bone tumor, constitutes 75% in young patients, mainly affects bones of the lower extremities. There is no effective method to prevent this type of cancer and it can induce amputation. Beta-sitosterol (BS) is a plant compound. Studies have shown immunomodulatory, antimutagenic, anti-inflammatory, and antioxidant biomedical properties. Benzopyrene (BZP) is a hydrocarbon, capable of inducing OS. Considering this background, this research project was raised. Therefore, the objective was to determine, in a model of bone carcinogenesis in rats, the chemotherapeutic activity of beta-sitosterol in the development of osteosarcoma. Neoplastic lesions were induced by perifemoral administration of BZP. From the 7th to the 9th week BS was administered orally. The weight of the rats was recorded, blood samples were taken for genotoxicity studies; biochemical tests were performed to determine sedimentation rate (ESR), alkaline phosphatase (FA) and lactic dehydrogenase (DHL). At the ninth week, euthanasia was performed, femurs, tibiae, liver and lungs were removed for histopathological study.pt_BR
Idioma: dc.language.isoenpt_BR
Palavras-chave: dc.subjectOsteosarcomapt_BR
Título: dc.titlePRELIMINARY RESULTS IN THE EVALUATION OF THE CHEMOTHERAPY ACTIVITY OF BETA-SITOSTEROL IN A MODEL OF OSTEOSARCOMA IN RATS (Atena Editora)pt_BR
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