THE ROLE OF VITAMIN D IN THE DEVELOPMENT/WORSEAGE OF MOOD DISORDERS, WITH A FOCUS ON BIPOLAR AFFECTIVE DISORDER AND DEPRESSION (Atena Editora)

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Autor(es): dc.contributor.authorSILVA, JOVANNA EDUARDA COELHO-
Autor(es): dc.contributor.authorCASTILHAS, JÉSSICA HIPÓLITO-
Autor(es): dc.contributor.authorSOUSA, SAMANTHA COSTA DE-
Autor(es): dc.contributor.authorGUIMARÃES, ANA CAROLINA DE SOUSA-
Autor(es): dc.contributor.authorGAMA, JAMILE POMPERMAIER-
Autor(es): dc.contributor.authorSOUSA, LARA CRISTINA VIEIRA-
Autor(es): dc.contributor.authorMOREIRA, LEONARDO CARUBA-
Autor(es): dc.contributor.authorRIBEIRO, MARINA MOREIRA-
Autor(es): dc.contributor.authorMENELLI, HENRIQUE PESSOTI-
Autor(es): dc.contributor.authorPENHA, TAINARA PAULA DA ANUNCIAÇÃO-
Autor(es): dc.contributor.authorREIS, MARIA ANGÉLICA OTERO DE MELO DOS-
Autor(es): dc.contributor.authorSILVEIRA, MYRNA-
Data de aceite: dc.date.accessioned2023-07-13T11:30:40Z-
Data de disponibilização: dc.date.available2023-07-13T11:30:40Z-
Data de envio: dc.date.issued2023-06-30-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/733997-
Resumo: dc.description.abstractPurpose: examine the literature on the role of vitamin D in the evolution and exacerbation of mood disorders, with a focus on bipolar and depressive disorders. Methodology: Literature review in the PubMed database. Through the following search strategy: vitamin D AND (bipolar disorder OR mood disorders). After applying the inclusion and exclusion criteria, 15 articles were selected to compose the collection of this study. Results: Vitamin D plays two main roles in the body. The first is related to the regulation of the immune system, where it suppresses the production of pro-inflammatory cytokines and increases levels of anti-inflammatory ones. This role is relevant in the context of bipolar disorder, which is associated with increased pro-inflammatory cytokines. The second paper focuses on the mechanisms linked to depression, specifically in the hypothalamic-pituitary-adrenal axis. In this context, vitamin D acts as an antagonist of glucocorticoids, which are excessively active in these disorders. Furthermore, there is evidence that vitamin D can also regulate the formation of new neurons in the hippocampus. Final considerations: Vitamin D plays a significant role in the evolution and exacerbation of disorders, being essential for the proper functioning of the central nervous system and for the regulation of the immune system.pt_BR
Idioma: dc.language.isoenpt_BR
Palavras-chave: dc.subjectDepressionpt_BR
Título: dc.titleTHE ROLE OF VITAMIN D IN THE DEVELOPMENT/WORSEAGE OF MOOD DISORDERS, WITH A FOCUS ON BIPOLAR AFFECTIVE DISORDER AND DEPRESSION (Atena Editora)pt_BR
Tipo de arquivo: dc.typelivro digitalpt_BR
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