Understanding contemporary diseases under evolutionary medicine view (Atena Editora)

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MetadadosDescriçãoIdioma
Autor(es): dc.contributor.authorBURINI, ROBERTO CARLOS-
Data de aceite: dc.date.accessioned2023-07-04T13:45:53Z-
Data de disponibilização: dc.date.available2023-07-04T13:45:53Z-
Data de envio: dc.date.issued2023-06-22-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/732780-
Resumo: dc.description.abstractFrom the evolutionary theory, the body is not a product of design but a bundle of compromises shaped by natural selection to maximize reproduction or genetic fitness, not health. Hence, life history theory predicts the coordinated evolution of the traits contributing directly to fitness: age and size at maturation, number and size of offspring, number of reproductive events, and ageing and lifespan. Major constraints were famine and infection with the trade-offs of encephalization-gut size; growth-immunological defense and longevity-reproduction. The major functions involved in lifespan are maintenance, growth, reproduction, and defense, in which energy can be invested. For those, insulin resistance, sodium preservation and inflammation are seen as thriftiness in situations such as famine, water privation and infection. For then, emerged the thrifty genotype. An evolutionary view suggests that many genetic variants interact with environments and other genes during development to influence disease phenotypes. Therefore, it is possible to analyze a great number of diseases in terms of adaptive vulnerabilities connected to our phylogenetic inheritance, such as human bodily inadequacies in relation to the modern environment. This means that current diseases such as obesity, T2D, essential hypertension, dyslipidemia and metabolic syndrome may result from the mismatch of our ancestral thrifty genotype with the contemporary way of life throughpt_BR
Idioma: dc.language.isoenpt_BR
Palavras-chave: dc.subjectMedicinept_BR
Título: dc.titleUnderstanding contemporary diseases under evolutionary medicine view (Atena Editora)pt_BR
Tipo de arquivo: dc.typelivro digitalpt_BR
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