MODE OF ACTION AND METABOLIC PATHWAYS OF CLEMBUTEROL IN BOVINE (Atena Editora)

Abstract

Clenbuterol considered as a powerful broncho-vase-dilator, used to control respiratory diseases, both in animals and in humans; Clb is a ß2-adrenergic agonist (ß2-AA), which causes an increase in muscle mass in birds, pigs, cattle and sheep, however, the metabolic routes to date are not well elucidated; The objective of this study was to determine the metabolites that arise with the intake of clenbuterol and its possible derivatives that are stored in the liver, pancreas, adrenal gland, muscles and genital organs, mainly in cattle. Fat content is dramatically reduced when clenbuterol is used as an anabolic, meaning anabolic, when Clb is administered orally or intramuscularly above the therapeutic dose, between 5 and 10 times its therapeutic concentration (0.8µg/body weight). twice daily). For this study, 17 different metabolites were measured to determine which metabolic parameters are disturbed, preventing homeostasis at the level of the different organs in which it intervenes. The study showed that there are several metabolites that are altered by clenbuterol, among these we have: glucose, triglycerides, alkaline phosphatase, gamma glutamyl transferase, transaminases (ALT/GPT y AST/GOT), lactic dehydrogenase, prostatic and non-prostatic acid phosphatase, cholesterol, and calcium. This indicates that it has an effect on altering the metabolism of several metabolic pathways, contributing to its lipolytic and antilipogenic activity and induces nitrogen retention, increases glycolysis, lactate production and oxygen consumption, increases levels of glucose, which varies according to the time of treatment, since at the level of the pancreas insulin decreases and adipocytes are less sensitive to this hormone, there is an increase in the use of energy, bringing with it an increase in body temperature-thermogenesis.