CLINICAL REPERCUSSIONS OF HORMONAL DISORDERS IN CHRONIC KIDNEY DISEASE (Atena Editora)

Abstract

When the functional capacity of the kidney is chronically impaired by any mechanism, there is the manifestation of chronic kidney disease (CKD), there is the manifestation of chronic kidney disease (CKD). Unlike the role of filtration, reabsorption and elimination considered in the diagnosis of the disease, however, the hormonal regulation exerted by the kidney, which is also compromised, is usually less valued by the general or technical population. The fact is that the kidneys secrete different substances, through specific secretory cells, many of which are not yet well defined, which act as hormones that regulate the functioning of the organism and, in the face of a dysfunctional kidney, this imbalance manifests a series of other symptoms and complications. This study, therefore, aims to recognize the clinical repercussions of hormonal disorders present in chronic kidney disease in order to seek a more effective approach to the patient. METHODOLOGY: This is a literature review where 12 articles were selected from 2004 to 2021 correlated with different aspects of the theme, regardless of the country of origin, as the association of the descriptors used is still quite restricted. After this selection, the main hormonal dysfunctions with their respective pathogens and clinical repercussions were presented. RESULTS: Calcitriol deficiency disorders, parathyroid hormone elevation, erythropoietin and iron deficiencies, ammonia production, renal nitric oxide production, and reduced sex hormone synthesis have been described. CONCLUSIONS: For the improvement of knowledge about the aforementioned disorders and for a better therapeutic approach to these hormonal complications, new sources of scientific production that aim to establish predictive factors and pathogenic reversion to control another aspect of the CKD spectrum are of paramount importance.