Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor.author | Correia, Maria Andreza Bezerra | - |
Autor(es): dc.contributor.author | Lins, Thiago Ubiratan Lins e | - |
Autor(es): dc.contributor.author | Cavalcanti, Nara Gualberto | - |
Autor(es): dc.contributor.author | Pereira, Michelly Cristiny | - |
Autor(es): dc.contributor.author | Rêgo, Moacyr Jesus Barreto de Melo | - |
Autor(es): dc.contributor.author | Kron-Rodrigues, Meline Rossetto | - |
Autor(es): dc.contributor.author | Marques, Claudia Diniz Lopes | - |
Autor(es): dc.contributor.author | Pitta, Maira Galdino da Rocha | - |
Data de aceite: dc.date.accessioned | 2021-12-02T15:14:29Z | - |
Data de disponibilização: dc.date.available | 2021-12-02T15:14:29Z | - |
Data de envio: dc.date.issued | 2021-11-16 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/capes/643661 | - |
Resumo: dc.description.abstract | Concentrations of serum IL-17 have been found at high levels in patients with AS. The role of serum IL-17 in ankylosing spondylitis (AS) was investigated through a meta-analysis undertaken to examine the correlation between AS disease activity and serum levels of IL-17 in AS compared to healthy controls and AS patients. Searches were performed in PubMed, ScienceDirect, Cochrane, and Lilacs databases for pertinent case-control studies using with the descriptors “Spondylitis, Ankylosing” and “Interleukin-17”. Expression in relation to healthy controls and correlation of IL-17 with BASDAI were plotted using Review Manager 5.3 software. Quality assessment of each eligible study used the Newcastle-Ottawa Scale. Thirteen case-control studies were selected for this meta-analysis and contained a pooled total of 752 AS patients and 607 healthy controls. Our main result revealed strikingly higher levels of serum IL-17 in AS patients, compared to healthy controls. Pooled mean difference 14.59, pooled risk ratios (RRs) with 95% confidence intervals (CIs) 7.73, 21.45; p<0.00001. Serum IL-17 is highly expressed in serum of patients with AS and is related to disease activity. The treatment in use significantly influenced IL-17; however, we did not observe a significant difference in the expression of IL-17 in the treatment of patients taking anti-TNF, proving that it does not interfere in this pathway. | pt_BR |
Idioma: dc.language.iso | en | pt_BR |
Palavras-chave: dc.subject | CASE CONTROL STUDIES | pt_BR |
Título: dc.title | ELEVATED SERUM LEVELS OF IL-17 DURING DISEASE ACTIVITY OF ANKYLOSING SPONDYLITIS: A SYSTEMATIC REVIEW WITH META-ANALYSIS (Atena Editora) | pt_BR |
Tipo de arquivo: dc.type | livro digital | pt_BR |
Aparece nas coleções: | Livros digitais |
Arquivos associados: | ||||
---|---|---|---|---|
ELEVATED SERUM LEVELS OF.pdf | 387 kB | Adobe PDF | /bitstream/capes/643661/1/ELEVATED SERUM LEVELS OF.pdfDownload |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: