RELATIONSHIP BETWEEN COVID-19 VACCINES AND GUILLAIN-BARRÉ SYNDROME: A REVIEW OF THE LITERATURE (Atena Editora)

Abstract

Guillain-Barré syndrome is an immune mediated inflammatorypolyradiculoneuropathy associated with numerous viral infections and the adverse reaction to some vaccines, including the vaccine for COVID-19. This is a systematic review of the literature where data collection was performed in the Databases PubMed (NCBI), Virtual Health Library (VHL) and Google Scholar, in october/2021, which aims to verify the prevalence of this adverse reaction in the world, considering the advance of vaccination for COVID-19 in the last months of 2021. Most of the patients who developed the syndrome did not present previous comorbidities, but all were adults, and the youngest person was a 25-year-old woman. The GBS presentations were the most varied, ranging from rapidly reversible unilateral paralysis to severe conditions requiring advanced respiratory support and evolving with sepsis due to white aspiration pneumonia. All patients underwent a large number of tests, which were mostly within the normal range, and the test was the analysis of cerebrospinal fluid. Almost all patients were treated with intravenous immunoglobulin, except for one patient who had no major systemic symptoms, most of which had almost complete remission of the condition with a return to activities of daily living. GBS is a potentially serious disease with low general incidence, several are the factors that can trigger its onset, among them vaccines stand out, however, the benefit of protecting againstCOVID-19 outweighs the risk of developing GBS.