Long-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.creatorTomaz, Carlos Alberto Bezerra-
Autor(es): dc.creatorSilva, A.C.F.-
Autor(es): dc.creatorNogueira, Paulo José de Campos-
Data de aceite: dc.date.accessioned2024-07-22T12:00:52Z-
Data de disponibilização: dc.date.available2024-07-22T12:00:52Z-
Data de envio: dc.date.issued2011-02-01-
Data de envio: dc.date.issued2011-02-01-
Data de envio: dc.date.issued1997-
Fonte completa do material: dc.identifierhttp://repositorio.unb.br/handle/10482/6713-
Fonte completa do material: dc.identifierhttps://dx.doi.org/10.1590/S0100-879X1997000200011-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/capes/794114-
Descrição: dc.descriptionABSTRACT-
Descrição: dc.descriptionWe investigated the long-lasting effect of peripheral injection of the neuropeptide substance P (SP) and of some N- or C-terminal SP fragments (SPN and SPC, respectively) on retention test performance of avoidance learning. Male Wistar rats (220 to 280 g) were trained in an inhibitory step-down avoidance task and tested 24 h or 21 days later. Immediately after the training trial rats received an intraperitoneal injection of SP (50 µg/kg), SPN 1-7 (167 µg/kg) or SPC 7-11 (134 µg/kg). Control groups were injected with vehicle or SP 5 h after the training trial. The immediate post-training administration of SP and SPN, but not SPC, facilitated avoidance behavior in rats tested 24 h or 21 days later, i.e., the retention test latencies of the SP and SPN groups were significantly longer (P<0.05, Mann-Whitney U-test) during both training-test intervals. These observations suggest that the memory-enhancing effect of SP is long-lasting and that the amino acid sequence responsible for this effect is encoded by its N-terminal part.-
Formato: dc.formatapplication/pdf-
Direitos: dc.rightsAcesso Aberto-
Palavras-chave: dc.subjectSubstância P-
Palavras-chave: dc.subjectMemória de longa duração-
Título: dc.titleLong-lasting mnemotropic effect of substance P and its N-terminal fragment (SP1-7) on avoidance learning-
Aparece nas coleções:Repositório Institucional – UNB

Não existem arquivos associados a este item.