Insights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca2+ free and bound states

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMurakami, M. T.-
Autor(es): dc.creatorGabdoulkhakov, A.-
Autor(es): dc.creatorGenov, N.-
Autor(es): dc.creatorCintra, A. C. O.-
Autor(es): dc.creatorBetzel, C.-
Autor(es): dc.creatorArni, R. K.-
Data: dc.date2014-05-20T14:02:18Z-
Data: dc.date2014-05-20T14:02:18Z-
Data: dc.date2006-05-01-
Data de aceite: dc.date.accessioned2014-11-17T16:26:04Z-
Data de disponibilização: dc.date.available2014-11-17T16:26:04Z-
Data de envio: dc.date.issued2014-11-17-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biochi.2005.10.014-
Fonte completa do material: dc.identifierBiochimie. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 88, n. 5, p. 543-549, 2006.-
Fonte completa do material: dc.identifier0300-9084-
Fonte completa do material: dc.identifierhttp://base.repositorio.unesp.br/handle/11449/21958-
Fonte completa do material: dc.identifier10.1016/j.biochi.2005.10.014-
Fonte completa do material: dc.identifierWOS:000239270500015-
Fonte: dc.identifier.urihttp://www.educapes.capes.gov.br/handle/capes/49060-
Fonte: dc.identifier.urihttp://www.educapes.capes.gov.br/handlecapes/49060-
Descrição: dc.descriptionThe electrophile Ca2+ is an essential multifunctional co-factor in the phospholipase A(2) mediated hydrolysis of phospholipids. Crystal structures of an acidic phospholipase A(2) from the venom of Bothrops jararacussu have been determined both in the Ca2+ free and bound states at 0.97 and 1.60 angstrom resolutions, respectively. In the Ca2+ bound state, the Ca2+ ion is penta-coordinated by a distorted pyramidal cage of oxygen and nitrogen atoms that is significantly different to that observed in structures of other Group I/II phospholipases A(2). In the absence of Ca2+, a water molecule occupies the position of the Ca2+ ion and the side chain of Asp49 and the calcium-binding loop adopts a different conformation. (c) 2005 Elsevier SAS. All rights reserved.-
Formato: dc.format543-549-
Idioma: dc.languageeng-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationBiochimie-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectsnake venom-
Palavras-chave: dc.subjectphospholipases A(2)-
Palavras-chave: dc.subjectCa2+ coordination-
Palavras-chave: dc.subjectanticoagulant activity-
Palavras-chave: dc.subjectX-ray analysis-
Título: dc.titleInsights into metal ion binding in phospholipases A(2): ultra high-resolution crystal structures of an acidic phospholipase A(2) in the Ca2+ free and bound states-
Tipo de arquivo: dc.typeoutro-
Aparece nas coleções:Repositório Institucional - Unesp

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