Serotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDe Gobbi, JIF-
Autor(es): dc.creatorDe Luca, L. A.-
Autor(es): dc.creatorMenani, Jose Vanderlei-
Data: dc.date2014-05-20T13:45:42Z-
Data: dc.date2014-05-20T13:45:42Z-
Data: dc.date2000-10-13-
Data de aceite: dc.date.accessioned2014-11-17T16:20:51Z-
Data de disponibilização: dc.date.available2014-11-17T16:20:51Z-
Data de envio: dc.date.issued2014-11-17-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(00)02784-0-
Fonte completa do material: dc.identifierBrain Research. Amsterdam: Elsevier B.V., v. 880, n. 1-2, p. 131-138, 2000.-
Fonte completa do material: dc.identifier0006-8993-
Fonte completa do material: dc.identifierhttp://base.repositorio.unesp.br/handle/11449/16092-
Fonte completa do material: dc.identifier10.1016/S0006-8993(00)02784-0-
Fonte completa do material: dc.identifierWOS:000089955600014-
Fonte: dc.identifier.urihttp://www.educapes.capes.gov.br/handle/capes/44563-
Fonte: dc.identifier.urihttp://www.educapes.capes.gov.br/handlecapes/44563-
Descrição: dc.descriptionIt has been shown that the serotonergic mechanisms of the lateral parabrachial nucleus (LPBN) inhibit NaCl intake in different models of angiotensin II (ANG II)-dependent NaCl intake in rats. However, there is no information about the involvement of LPBN serotonergic mechanisms on NaCl intake in a model of NaCl intake not dependent on ANG II like deoxycorticosterone (DOCA)-induced NaCl intake. Therefore, in this study we investigated the effects of bilateral injections of serotonergic agonist and antagonist into the LPBN on DOCA-induced 1.8% NaCl intake in rats. Male Holtzman rats were treated with s.c. DOCA (10 mg/rat each every 3 days). After a period of training, in which the rats had access to 1.8% NaCI during 2 h for several days, the rats were implanted with stainless steel cannulas bilaterally into the LPBN. Bilateral injections of the serotonergic receptor antagonist methysergide (4 mug/0.2 mul each site) in the LPBN increased 1.8% NaCI intake (32.2+/-3.9 versus vehicle: 15.0+/-1.6 ml/2 h, n = 10) and water intake (11.5+/-3.5 versus vehicle: 3.2+/-1.0 ml/2 h). Injections of the serotonergic 5HT(2A/2C) receptor agonist DOI (5 mug/0,2 mul each site) in the LPBN reduced 1.8% NaCl intake (6.8+/-1.7 versus saline: 12.4+/-1.9 ml/2 h, n = 10) and water intake (2.2+/-0.8 versus saline: 4.4+/-1.0 ml/2 h). Besides the previously demonstrated importance for the control of ANG II-dependent water and NaCl intake, the data show that the serotonergic inhibitory mechanisms of the LPBN are also involved in the control of DOCA-induced NaCl intake. (C) 2000 Elsevier B.V. B.V. All rights reserved.-
Formato: dc.format131-138-
Idioma: dc.languageeng-
Publicador: dc.publisherElsevier B.V.-
Relação: dc.relationBrain Research-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectdeoxycorticosterone-
Palavras-chave: dc.subjectNaCl intake-
Palavras-chave: dc.subjectwater intake-
Palavras-chave: dc.subject5HT-
Palavras-chave: dc.subjectLPBN-
Título: dc.titleSerotonergic mechanisms of the lateral parabrachial nucleus on DOCA-induced sodium intake-
Tipo de arquivo: dc.typeoutro-
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