A Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorChung, Man Chin-
Autor(es): dc.creatorBosquesi, Priscila Longhin-
Autor(es): dc.creatordos Santos, Jean Leandro-
Data: dc.date2014-05-20T13:24:52Z-
Data: dc.date2014-05-20T13:24:52Z-
Data: dc.date2011-11-01-
Data de aceite: dc.date.accessioned2014-11-17T16:12:57Z-
Data de disponibilização: dc.date.available2014-11-17T16:12:57Z-
Data de envio: dc.date.issued2014-11-17-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2174/138161211798194512-
Fonte completa do material: dc.identifierCurrent Pharmaceutical Design. Sharjah: Bentham Science Publ Ltd, v. 17, n. 32, p. 3515-3526, 2011.-
Fonte completa do material: dc.identifier1381-6128-
Fonte completa do material: dc.identifierhttp://base.repositorio.unesp.br/handle/11449/7832-
Fonte completa do material: dc.identifier10.2174/138161211798194512-
Fonte completa do material: dc.identifierWOS:000299637000005-
Fonte: dc.identifier.urihttp://www.educapes.capes.gov.br/handle/capes/37874-
Fonte: dc.identifier.urihttp://www.educapes.capes.gov.br/handlecapes/37874-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionIn therapeutics research, the nitro compounds are part of an important group of drugs with multiple pharmacological activities. However, in drug design, the inclusion of a nitro group in a molecule changes the physico-chemical and electronic properties and is associated with increased mutagenicity and carcinogenicity. In addition, several studies have related the relationship between the antimicrobial and/or anti-protozoal activity and the mutagenic effect to reduction of the nitro group. This work reviews the toxicity of nitro compounds and shows how the use of prodrugs can increase the biological activity and decrease the genotoxicity of nitro compounds, without any modification in nitro reduction behavior, but rather by physico-chemical improvement. Examples are given of metronidazole and nitrofurazone prodrugs.-
Formato: dc.format3515-3526-
Idioma: dc.languageeng-
Publicador: dc.publisherBentham Science Publ Ltd-
Relação: dc.relationCurrent Pharmaceutical Design-
Direitos: dc.rightsclosedAccess-
Palavras-chave: dc.subjectProdrugs-
Palavras-chave: dc.subjectnitro-compounds-
Palavras-chave: dc.subjectmetronidazol-
Palavras-chave: dc.subjectnitrofurazone-
Palavras-chave: dc.subjectgenotoxicity-
Palavras-chave: dc.subjectphysico-chemical properties-
Título: dc.titleA Prodrug Approach to Improve the Physico-Chemical Properties and Decrease the Genotoxicity of Nitro Compounds-
Tipo de arquivo: dc.typeoutro-
Aparece nas coleções:Repositório Institucional - Unesp

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